A high-yield, one-pot, scalable reaction facilitates the production of biologically relevant amide compounds using less reactive nitrogen-containing heterocyclic compounds and carboxylic acid without ...

A team at UNC-Chapel Hill has developed a new process for synthesizing amides in a 100% atom-economical, sustainable fashion using Earth-abundant, environmentally friendly cobalt. UNC-Chapel Hill ...

Even though amide bonds are everywhere—they hold proteins together and are essential components in many drugs—forging this molecular motif in a reaction flask can be challenging. For example, making ...

Medicines come from chemical reactions, and better chemical reactions lead to better medicines. Yet, the most popular reaction used in drug discovery, called the amide coupling, makes an inherently ...

Figure 2. (Top) Adipic acid reacts with hexamethylenediamine to form an amide bond (red line), just like the reaction in Figure 1, but there's a big difference. The reaction product that I've called ...

Conventional methods for N-acylation of heterocyclic, nitrogen-containing compounds are notoriously inefficient, producing low yields and often involving preactivated reagents, strong metal bases and ...

A peptide bond is an amide type of covalent chemical bond linking two consecutive alpha-amino acids from C1 (carbon number one) of one alpha-amino acid and N2 (nitrogen number two) of another, along a ...