The chaperonin system is pivotal in maintaining cellular proteostasis through its ATP-dependent mediation of protein folding. Among these, the TRiC/CCT complex has emerged as a key molecular machine ...

Scientists have studied molecular interactions in the chaperonin protein GroEL. GroEL is alternately bound and unbound by a co-chaperonin, GroES. Against expectations, the 'football' complex -- where ...

Analyzing ring moiety additions to the A-ring of camptothecin. This is an ASCO Meeting Abstract from the 2015 ASCO Annual Meeting I. This abstract does not include a full text component.

Researchers have found a new way to track metastatic cancer cells in the body, which in the future could help identify cancer earlier and give patients more treatment options. UCF researchers have ...

A team of researchers at Roswell Park Comprehensive Cancer Center, led by Dhyan Chandra, Ph.D., has discovered a new therapeutic target for neuroendocrine prostate cancer, a rare and hard-to-treat ...