The Cre recombinase from bacteriophage P1 has been widely used to induce DNA sequence-specific recombination in mammalian cells 1,2. LoxP sites, which serve as targets of Cre-mediated recombination in ...

Strategies for altering constitutional or somatic genotype in mice are well established, but approaches to generate mosaic genotypes in mouse tissues are limited. We showed that a functionally ...

The Cre recombinase (Cre) from bacteriophage P1 is an important tool for genetic engineering in mammalian cells. We constructed lentiviral vectors that efficiently deliver Cre in vitro and in vivo.

Cre-loxP, a powerful tool for preclinical cancer research, possesses intrinsic pitfalls that can alter result accuracy, according to an editorial paper in Oncoscience. Cancer and other diseases could ...

Chances are if you use mice in your research, you are intimately acquainted with the Cre/LoxP recombination system. (For the uninitiated out there, this is a system to achieve tissue- or cell ...

New tools are now available for generating specifically targeted genetic mutations in bacteria, mammalian cells and mice. The new recombinase, Dre, is similar to its predecessor, Cre, but targets ...

Cornell scientists have engineered E. coli to act as a sensitive biosensor for monitoring environmental arsenic, a toxic ...

Researchers design a Cas9 enzyme that cuts DNA only in the presence of particular drug. A series of rodent experiments showed that even with abundant food and water, personal space is essential to ...

(Nanowerk News) A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has developed two new genome editing ...

Recombinase-mediated cassette exchange (RMCE) is a powerful tool for the modification of the Drosophila genome and its utility has now been extended through the use of another site-specific ...