DNA helicases are motor proteins that translocate along nucleic acids to separate complementary strands, a step essential for replication, repair and recombination. By unwinding duplex DNA and ...
Eukaryotic DNA replication relies on a highly orchestrated series of events centred on the Cdc45–MCM–GINS (CMG) helicase complex. Origin licensing begins in G1 phase with loading of a double hexamer ...
For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event for DNA to be the molecule that codes all life. A new study from King ...
Researchers have identified HELQ as a key regulator of DNA replication stress responses, explaining why cells lacking the ...
RO7589831, a new drug from Roche, is first in a new class of drugs called Werner helicase inhibitors Drug works similarly to other DNA damage repair inhibitors, such as PARP inhibitors This class of ...
Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections - and, alas, extraordinarily difficult to target with drugs. Now, new ...
An international collaborative research team has discovered that G-quadraplex DNA (G4-DNA) accumulates in neurons and dynamically controls the activation and repression of genes underlying long-term ...
DNA repair mechanism: HELQ helicase remodels stalled replication forks into stable structures, preventing harmful mutations under replication stress. Advanced imaging tool: RF-SIRF maps reversed forks ...
New research shows that the nuclease domain of the E. coli RecBCD helicase plays a key role in regulating DNA binding and the extent of base pair melting during double-strand break repair. Deleting ...
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