Readout of distinctly modified histones by specialized ‘effector’ proteins, such as readers, writers and erasers, constitutes a key mechanism for transducing molecular events at chromatin to ...

Different prognostic value of cytokeratin-19 mRNA-positive circulating tumor cells according to estrogen receptor status in early breast cancer No significant financial relationships to disclose. This ...

Methylation is a key post-translational modification (PTM) of mammalian proteins and nucleic acids where unique enzymes known as methyltransferases (MTases) transfer methyl groups to a variety of ...

While each cell contains the complete genetic blueprint of an organism, chemical marks on the DNA—so-called epigenetic modifications—control which genes are active when and where. A team led by ...

AptaFluor SAH Methyltransferase Assay is a high-throughput enzymatic assay for SAM-dependent methyltransferases. The assay uses a naturally existing SAH-sensing RNA aptamer, or riboswitch, which binds ...