Image of mouse embryos at the 2-cell stage visualised by light microscopy. Two blastomeres (cells) can be seen inside the zona pellucida (a “shell-like” protective outer layer) of each embryo. Credit: ...

A recent study published in Cell investigates how lamina-associated domains (LADs) contribute to nuclear genome organization in early-stage mouse embryos. Focusing on the zygote and two-cell stages, ...