Researchers at the VIB-KU Leuven Center for Cancer Biology have uncovered how a unique interaction between two cellular compartments, namely the endoplasmic reticulum (ER) and mitochondria, can act as ...

Mitochondrial dysfunction manifests as structural damage (swelling, cristae rupture, increased volume/decreased numerical density), energy metabolism abnormalities (reduced COX and Complex I-III ...

Timeline diagram depicting essential discoveries in the field of ferroptosis research. The exploration of ferroptosis originated from the identification of system xc-, which was initially reported in ...

An international team of researchers has discovered how cholesterol can disrupt the internal functioning of the heart by accumulating in the mitochondria of cardiomyocytes. They have also developed an ...

4-Hydroxynonenal (4-HNE) is a major byproduct of lipid peroxidation, a process exacerbated by mitochondrial dysfunction and oxidative stress. Accumulation of 4-HNE protein adducts has been reported in ...

Mitochondrial health testing is no longer just for scientists and athletes but a powerful new way to assess biological age and guide personalized longevity strategies. LA Times Studios may earn ...

Mutations in the lipid transporter ABCA7 are known to elevate the risk of Alzheimer’s disease, but how they do so has been murky. Now, scientists led by Li-Huei Tsai at MIT in Cambridge, Massachusetts ...

In a step toward treating mitochondrial diseases, researchers at the University Medical Center Utrecht and their colleagues have used mitochondrial base editing (mtBE) to successfully edit harmful ...