Congenital urinary tract obstruction is the single most important cause of childhood chronic kidney disease. We have previously demonstrated that human and primate fetal obstruction impairs the ...

In the embryonic kidney, three types of precursor cells interact to form three-dimensional structures of the kidney: nephron progenitor cells, ureteric buds, and interstitial progenitor cells. Methods ...

Nephron development in mammals involves a coordinated series of cellular and molecular events that convert undifferentiated progenitors into the functional filtering units of the kidney. The process ...

The kidney carries out important functions via microscopic functional units called nephrons. Researchers are investigating which factors control the formation and function of specific segments of the ...

“You’re on a chemotherapeutic and your oncologist may say that your dosage is X, while a nephrologist is telling you that the proximal tubules in your kidneys can’t handle it. You’re harming them.” ...

In the embryonic kidney, three types of precursor cells, nephron progenitor cells, ureteric buds, and interstitial progenitor cells, interact to form three-dimensional structures of the kidney.

In the embryonic kidney, three types of precursor cells interact with each other to form a three-dimensional structure. Previous studies successfully induced nephron structures via nephron progenitors ...