Cells rely on tiny molecules called microRNAs to tune which genes are active and when. Cells must carefully control the lifespan of microRNAs to prevent widespread disruption to gene regulation. A new ...

Proteins are the tiny machines that keep our cells running, and how long they last in the cell often determines how well they ...

Targeted protein degradation has opened up a new field of drug discovery with potential to treat previously 'undruggable' diseases. The work means new drugs can be much more accurately targeted at the ...

Lysosomes are the control centers for the metabolism of cells and tissues, including the brain. They break down defective proteins and other macromolecules into their basic building blocks.

Targeted protein degradation is a therapeutic strategy that utilizes the cell’s natural machinery to eliminate disease-causing proteins. The field traces its origins to the development of thalidomide ...

Therapeutics that leverage protein degradation as their primary mechanism of action appear to be a validated new therapeutic modality. The current clinical molecules are focused on degrading ...

Researchers have revealed how bacteria precisely control the genes that trigger cell division. The study shows that the MraZ protein, which normally forms a donut-shaped structure, must bend and ...

SAN MATEO, Calif.--(BUSINESS WIRE)--EpiBiologics, a leader in tissue-selective extracellular protein degradation, will be presenting new data demonstrating the unique capabilities of its EpiTAC ...

Researchers identified TBC1D9B as the off switch for ARL8B, a key regulator of lysosome positioning. This mechanism controls how cells adapt to nutrient stress and maintain metabolic balance.

When cancer-driving proteins resist various treatments, Northwestern University scientists have uncovered a new solution. Don't fight them—throw them in the cellular trash. In a new study published in ...