Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have identified novel mechanisms by which a metabolic derivative of vitamin A-all-trans retinoic ...

Why retinoic acid is effective in this setting but not against primary tumors, has been speculated about for nearly 50 years. Scientists resolved the mystery, showing the drug 'hijacks' a normal ...

Figure 6: Cell cycle analysis of HL-60 WT and FGR O.E cells. DNA histograms show FGR transfectants were enriched for relative number of G1/0 cells compared to the wt cells. Wild-type and FGR O.E cell ...

Retinoic acid, a vitamin A derivative, has long been used as a treatment in certain cases of neuroblastoma — but its effects vary depending on the disease context. While the drug has minimal impact on ...

Neuroblastoma is a solid tumor that occurs in children. When high-risk, the disease has a poor prognosis. Decades ago, adding the drug retinoic acid to neuroblastoma treatment increased survival by 10 ...

Researchers have synthesized enhanced vitamin K analogues that outperform natural vitamin K in promoting neuron growth. The new compounds, which combine vitamin K with retinoic acid, activate the ...

(L to R) Co-first and co-corresponding author Min Pan, PhD, co-first author Yinwen Zhang, PhD, St. Jude Department of Computational Biology, co-corresponding author John Easton, PhD, St. Jude ...