Schematic showing IL-6-induced STAT3-to-PI3K signaling switch in colorectal cancer stem cells, driving ZEB1-dependent PD-L1 expression and immune evasion. A landmark study published in Science ...

Schematic diagram of the IL-6/JAK/STAT3 signaling pathway activation in mouse liver macrophages. IRs, inhibitory receptors (IRs); ICIs, immune checkpoint inhibitors; IL-6, interleukin-6; ALT, alanine ...

Head and neck squamous cell carcinoma (HNSCC) is approximately the seventh most common cancer in humans with an estimated 900,000 new cases globally. As a surgeon, Jennifer Grandis, MD, a physician ...

Bayer has cleared out four cancer candidates from its early-stage pipeline, including a STAT3 inhibitor acquired as part of its buyout of Vividion Therapeutics. The Vividion asset in question, called ...

Previous research revealed that nuclear factor of activated T cells 1 (NFAT1) is a novel regulator of the mouse double minute 2 homolog (MDM2) oncogene, which acts by directly binding to the MDM2 P2 ...