Cellular aging is thought to be controlled, in part, by the chromosomes’ telomeres – end caps that protect our DNA. But the relationship may be much more complex than scientists thought, as new ...
A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of ...
In humans, telomeres are nucleoprotein complexes made up of tandem 5′TTAGGG3′ DNA repeats and associated proteins located at the ends of all 46 chromosomes. Telomere (TTAGGG)n tract loss beyond a ...
MAIA Biotechnology, Inc. ( MAIA) has dosed the first U.S. patient in its ongoing Phase 2 THIO-101 clinical trial evaluating Ateganosine, the company's telomere-targeting lead candidate, in third-line ...
Johns Hopkins Medicine researchers say they have found that specific variations in three genes related to maintaining the length of telomeres—the protective DNA endcaps on chromosomes—may explain up ...
Next-generation divalent agents show increased anticancer activity in preclinical in vitro and in vivo modelsCHICAGO, Sept (GLOBE ...
The length of telomeres that protect the ends of our chromosomes should be tightly regulated. Those that are too long predispose to cancer, and those that are too short lose their protective ability, ...
Researchers introduce the "Telomouse". By making a subtle genetic alteration in standard lab mice, they've made their telomeres, which protect the chromosome ends, more closely resemble those in ...
Researchers at the Johns Hopkins Kimmel Cancer Center and the Telomere Clinic at Johns Hopkins have identified a genetic syndrome in which unusually long telomeres—the protective caps at the ends of ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results