Background: At birth, coagulation system is activated resulting in thrombin formation in the newborn. In sick newborns, the coagulopathy may lead to bleeding or thrombotic complications. Known genetic ...

Historically, hemostasis has been divided into three parts: (1) blood vessel constriction, (2) primary hemostasis resulting in a platelet plug, and (3) plasmatic-based blood coagulation. However, in ...

To understand the pharmacology and mechanism of action of ximelagatran, a review of the formation and function of thrombin is warranted. [10] The generation of thrombin is limited under normal ...

Conversion of protein C to APC requires thrombin and thrombomodulin. The substrate preference of thrombin changes depending on whether thrombin is bound to thrombomodulin. When thrombin is not bound ...

The addition of omega-3 polyunsaturated fatty acids—found in fish oil—to dual antiplatelet therapy decreases thrombin formation and favorably alters fibrin clot properties in patients with coronary ...

Unfractionated heparin (UFH), the standard anticoagulant for cardiopulmonary bypass (CPB) surgery, carries a risk of post-operative bleeding and is potentially harmful in patients with heparin-induced ...

Oral direct thrombin inhibitors appear to increase the risk of myocardial infarction (MI) compared with warfarin in patients prescribed anticoagulants to prevent stroke. The findings, from a ...

CHAPEL HILL -- New research at the University of North Carolina at Chapel Hill has found that a fatty molecule on the surface of platelet cells is a regulator of blood coagulation. Besides its role in ...

Protein S activity is a test to judge your risk of blood clots. Blood clots that form in the veins are dangerous. Protein S is a substance that controls the blood clotting mechanism and prevents ...