An emerging theme from genome sequencing projects is heterogeneity in mutation rates across different regions of individual genomes. Various studies are now attempting to uncover the genomic and ...

Transcriptome sequencing demonstrated that most mutations also arose in genes that were minimally expressed in the mutated allele-bearing tumor and minimally expressed in the other tumors that lacked ...

Robertsonian translocation is the most common form of chromosomal translocation in humans. It means that two chromosomes, the structures that make up a person’s DNA, join together in an abnormal way.

Chromosomal translocations occur in leukemias, lymphomas, sarcomas and some epithelial tumors and some generate unique fusion proteins. These translocation products may provide tumor-specific targets ...

Shaw 5 has suggested that chromosomal aberrations involving only a portion of No. 21 may result in "partial-mongol" persons. Such cases may represent a possible method for identification of the genes ...

chromosomal translocations associated with two types of cancer, acute myeloid leukemia and Ewing's sarcoma, have been reproduced, for the first time in human cells, by scientists. The study's authors ...

Translocations are chromosomal "cut and paste" errors that drive many lymphomas, a type of blood cancer and the sixth most common form of cancer overall. This includes mantle cell lymphoma, a rare but ...

Translocations are chromosomal “cut and paste” errors that drive many lymphomas, a type of blood cancer and the sixth most common form of cancer overall. This includes mantle cell lymphoma, a rare but ...

Panel A shows a flat nasal bridge, and Panel B shows T-shaped midline teeth in a man with hypotelorism; these findings are characteristic of mild holoprosencephaly. Panel C shows a hand with ...

Translocation is a genetic abnormality in which part of a chromosome moves to another chromosome. Chromosomes are genetic structures within cells that hold genes. When translocation occurs, it causes ...

In an agricultural advancement, scientists have deciphered the genetic underpinnings of watermelon chromosomal translocations, the key to cultivating fruits with fewer seeds. The global demand for ...

Researchers at the Scripps Research Institute in Florida have made a clinical discovery that could help physicians develop new treatments for an oral cancer that affects the salivary glands, according ...