Many of the proteins that calmodulin binds are unable to bind calcium themselves, and use calmodulin as a calcium sensor and signal transducer. Calmodulin can also make use of the calcium stores in …

More than 300 calmodulin-binding proteins (calmodulin targets) have been identified to date (representative examples are summarized in Fig. 1). Among these, calmodulin-dependent enzymes …

Jul 4, 2017 · Calmodulin, or calcium-modulated protein, is a calcium-binding protein found in the cytoplasm of all eukaryotic cells. It interacts with many other proteins in the cell, and acts as a …

Calmodulin acts as an intermediary protein that senses calcium levels and relays signals to various calcium-sensitive enzymes, ion channels and other proteins. Calmodulin is a small dumbbell-shaped …

Calmodulin is a protein that binds to the intracellular face of GPCRs, such as the μ-opioid receptor, and helps in reducing GPCR signaling by affecting G-protein coupling.

Jul 1, 2011 · We studied the reorientation of the two major domains of calmodulin and the flexibility of the tether. The simulations shed light on the time-dependent availability of various target-specific …

Sep 9, 2024 · Calmodulin, a protein critically important for the regulation of all major cardiac ion channels, is the quintessential cellular calcium sensor and plays a key role in preserving cardiac …

Calmodulin is a small acidic protein (M r ≈ 16,700), the amino-acid sequence of which has been remarkably preserved during evolution. Early on, an analysis of its amino-acid sequence indicated …

Sep 30, 2025 · Ion channels can also be regulated by the universal Ca 2+ sensor Calmodulin (CaM), which was recently shown to bind TRPA1 in a Ca 2+ -dependent manner and affect its Ca 2+ …

Calmodulin is a ubiquitous, highly conserved protein that plays a critical role in numerous essential cellular functions, including Ca 2+ transport, cell motility, cytoskeletal assembly, protein …