CD135 - Wikipedia
Internal tandem duplications of FLT3 (FLT3-ITD) are the most common mutations associated with acute myelogenous leukemia (AML) and are a prognostic indicator associated with adverse disease outcome.
FLT3 Mutations in Acute Myeloid Leukemia: Key Concepts and ...
Mutations in FLT3 are the most common genetic alteration in AML, identified in approximately one third of newly diagnosed patients. FLT3 internal tandem duplication mutations (FLT3- ITD) are associated …
FLT3 gene: MedlinePlus Genetics
The FLT3 gene provides instructions for making a protein called fms-like tyrosine kinase 3 (FLT3), which is part of a family of proteins called receptor tyrosine kinases (RTKs). Learn about this gene and …
FLT3 Gene - GeneCards | FLT3 Protein | FLT3 Antibody
Nov 13, 2025 · Complete information for FLT3 gene (Protein Coding), Fms Related Receptor Tyrosine Kinase 3, including: function, proteins, disorders, pathways, orthologs, and expression.
Targeting FMS-like tyrosine kinase 3 (FLT3) in acute myeloid ...
Jan 1, 2025 · The link between AML and mutations in the gene encoding FMS-like tyrosine kinase 3 (FLT3) was established in 1997 when Yokota et al. identified the internal tandem duplication in the …
FLT3 Mutation and AML: Symptoms, Testing, and More - Healthline
Mar 29, 2022 · The FLT3 gene contains instructions for a protein called FLT3, which helps white blood cells grow. A mutation in this gene encourages the growth of too many abnormal white blood cells.
FLT3 | A Key Therapeutic Target in Acute Myeloid Leukemia
May 20, 2025 · Explore how FLT3 mutations drive disease through PI3K/AKT, STAT5 and MAPK pathways, and discover the emerging therapies, including selective inhibitors and CAR‑T …