Inflammasomes are cytosolic multiprotein complexes of the innate immune system responsible for the activation of inflammatory responses and cell death. [1][2] They are formed as a result of specific …

Oct 9, 2025 · In this review, we present a comprehensive overview of inflammasomes with an emphasis on the mechanistic principles that govern inflammasome formation. We also discuss the …

May 7, 2026 · Some intracellular pattern recognition receptors belonging to the Nod-like receptor, AIM2-like receptor, and pyrin family initiate the assembly of a multiprotein signaling platform called …

Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1β to engage innate immune defenses.

In this review, we explore the molecular structure and mechanism of activation of the inflammasome with a particular focus on inflammasome complexes expressed in humans.

The inflammasome is defined as a group of cytosolic multiprotein complexes involving NLR proteins and caspase-1, which can induce various biological responses such as depression-like behavior and …

Aug 13, 2025 · What is an inflammasome? An inflammasome is a cytosolic multiprotein complex that plays a critical role in the innate immune response by detecting pathogens and cellular stress signals.

We reviewed current research on the mechanisms of inflammasome activation and inflammasomes' contribution to autoimmune diseases. Inhibitors targeting inflammasome components were also …

4 days ago · A number of distinct inflammasome complexes have been identified, each with a unique PRR and activation triggers. The best characterized is the NLRP3 complex, which contains NLRP3, …

Sep 1, 2025 · Beyond pathogen defense, inflammasomes influence tissue regeneration, cell death pathways, and sterile inflammation, highlighting their role as integrative immune hubs.