In physical organic chemistry, a kinetic isotope effect (KIE) is the change in the reaction rate of a chemical reaction when one of the atoms in the reactants is replaced by one of its isotopes. [3]

Secondary kinetic isotope effect arises from isotopic substitution at a bond that is not being broken, and typically involve a change in bond hybridization or involvement of the bond in …

Aug 2, 2025 · The kinetic isotope effect (KIE) describes how replacing an atom with one of its isotopes—atoms of the same element with different masses due to varying neutron …

May 5, 2024 · Kinetic Isotope Effects (KIEs) are used to determine reaction mechanisms by determining rate limiting steps and transition states and are commonly measured using NMR …

What Are Kinetic Isotope Effects? A kinetic isotope effect is a mechanistic phenomenon wherein isotopically substituted molecules react at different rates. Isotopic substitution does not affect …

Kinetic isotope effects (KIE) occur when the substitution of an atom in a molecule with one of its isotopes changes the reaction rate. KIE provides insight into the reaction mechanism, …

The kinetic isotope effect refers to the difference in the rate of a chemical reaction when a light isotope of an element is replaced by a heavier isotope of the same element.

The kinetic isotope effect is defined as the ratio of the rate constants of reactions involving unlabelled and labelled species, primarily reflecting the influence of isotopic substitution on …

Jun 9, 2025 · Explore the fundamentals of Kinetic Isotope Effects and their significance in organic chemistry, including their impact on reaction rates and mechanisms.

The effect of isotopic substitution on a rate constant is referred to as a kinetic isotope effect.