NLRP3 - Wikipedia
NLRP3 is a component of the innate immune system that functions as a pattern recognition receptor (PRR) – a cytosolic sensor that responds to pathogen-associated molecular patterns …
The NLRP3 Inflammasome: An Overview of Mechanisms of ...
The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to …
The NLRP3 inflammasome: molecular activation and regulation ...
Apr 29, 2019 · NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular sensor that detects a broad range of microbial motifs, endogenous danger signals and …
NLRP3 inflammasome: From drug target to drug discovery
Jun 1, 2025 · NLRP3 triggers cytokine storms and neuroinflammation, contributing to inflammatory diseases. Emerging therapies target NLRP3 via nuclear receptors …
The NLRP3 inflammasome: contributions to inflammation-related ...
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin …
Frontiers | The NLRP3 Inflammasome Pathway: A Review of ...
Jun 10, 2022 · The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating the innate immune system and inflammatory signaling. Upon activation by PAMPs …
The NLRP3 Inflammasome Pathway: A Review of Mechanisms and ...
Studies using small molecules and biologics targeting the NLRP3 inflammasome pathway have shown positive outcomes in treating various disease pathologies by blocking chronic …